J. Royet

Host pathogen interaction in Drosophila

 

Drosophila larval gut infected with GFP labelled bacteria

Animals must battle constantly against harmful bacteria that enjoy living off their food, or inside them. An important line of defence for infected hosts is the immune system which fights pathogenic bacteria. A shrewder strategy for animals would be to avoid contact with dangerous microbes or to minimise the effect of pathogen on host fitness. Although the mechanisms by which bacteria are triggering immune responses are well known, their effects on eukaryotes physiology and behaviour are largely unstudied. Our laboratory is using the Drosophila system to study some important questions related to host pathogen interactions such as

  • How are gut cells able to tolerate commensal bacteria while eliminating pathogenic ones?
  • What are the influences of gut associated bacteria on brain activity?
  • How do infectious bacteria modulate fly behavior?

 

Links

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Julien Royet

Group leader

+33(0)4 91 26 93 38

julien.royet@univ-amu.fr

Julien is a professor of Cell biology and head of the Development and Immunology Master Program at Aix Marseille University. He is working on the mechanisms of innate immunity in Drosophila melanogaster. He received his PhD degree from the University of Lyon, France, and completed postdoctoral training at the University of Pennsylvania, Philadelphia, USA, and at the European Molecular Biology Laboratory in Heidelberg, Germany. From 1999 to 2005, he worked at the Institut de Biologie Moléculaire et Cellulaire in Strasbourg, France.

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Ambra Masuzzo

PhD student

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Delphine Chaduli

Technical staff

+33(0)4 91 26 93 44

delphine.chaduli@univ-amu.fr

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Bernard Charroux

Researcher

+33(0)4 91 26 93 44

bernard.charroux@univ-amu.fr

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Florence Capo

PhD student

+33(0)4 91 26 93 44

florence.capo@univ-amu.fr