P.F. Lenne

Physical approaches to cell dynamics and tissue morphogenesis

 

Tissue morphogenesis relies on the interplay between mechanical and biochemical events.
We integrate physical approaches (optics/microscopy/mechanics/modelling) and experimental biology to study quantitatively these two key aspects of morphogenesis. More specifically we study:

 

  1. The assembly and dynamics of adhesion complexes at cell interfaces in vivo, using Drosophila as a model system;
  2. The mechanics of cell interfaces and force transmission during tissue shaping ;
  3. The dynamics of ligands/receptors during tissue polarization, using in C. elegans as a model system.

 

 

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Pierre-françois Lenne

Coordinator, Group leader

+33 (0)4 91 26 93 65

pierre-francois.lenne@univ-amu.fr

Pierre-François studied physics at the University of Paris and Ecole Normale Supérieure of Paris, France, before completing his PhD in soft matter physics at the University of Grenoble, France. After postdoctoral research in the cell biology and biophysics unit of EMBL (Heidelberg, Germany), he joined the National Centre for Scientific Research (CNRS) as a Chargé de Recherche (research scientist) in the Fresnel Institute of Marseille. Group leader at the Institute for Developmental Biology of Marseilles-Luminy (IBDM) and CNRS research director since 2009, his current research focuses on cell dynamics and mechanics in the context of tissue morphogenesis.

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Ali Hashmi

PhD student

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Raphaël Clément

Researcher

Title project: Tissue mechanics

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Pruthvi Chavadimane

PhD student

Title project: Cell shape changes during tissue morphogenesis

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Claire Chardès

Technical staff

Title project: Advanced microscopy for cell dynamics

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Pierre Recouvreux

Researcher

Title project: Tissue polarization