Tissue morphogenesis relies on the interplay between mechanical and biochemical events.
We integrate physical approaches (optics/microscopy/mechanics/modelling) and experimental biology to study quantitatively these two key aspects of morphogenesis. More specifically we study:
- The assembly and dynamics of adhesion complexes at cell interfaces in vivo, using Drosophila as a model system;
- The mechanics of cell interfaces and force transmission during tissue shaping ;
- The dynamics of ligands/receptors during tissue polarization, using in C. elegans as a model system.
- More information here