P.F. Lenne

Physical approaches to cell dynamics and tissue morphogenesis

Tissue morphogenesis relies on the interplay between mechanical and biochemical events.
We integrate physical approaches (optics/microscopy/mechanics/modelling) and experimental biology to study quantitatively these two key aspects of morphogenesis. More specifically we study:

The assembly and dynamics of adhesion complexes at cell interfaces in vivo, using Drosophila as a model system;
The mechanics of cell interfaces and force transmission during tissue shaping ;
The dynamics of ligands/receptors during tissue polarization, using in C. elegans as a model system.

Molecular clustering in the cell: from weak interactions to optimized functional architectures.

Recouvreux P, Lenne PF.

Curr Opin Cell Biol. 2016 Feb;38:18-23. PMID: 26829487

PubMed

PUBLICATION

September 18th 2015

Direct laser manipulation reveals the mechanics of cell contacts in vivo

Bambardekar K, Clément R, Blanc O, Chardès C, Lenne PF.

Proc Natl Acad Sci U S A. 2015 Feb 3;112(5):1416-21. PMID: 25605934

PubMed

PUBLICATION

July 22nd 2015

Calcium Spikes in Epithelium: study on Drosophila early embryos

Markova O, Sénatore S, Chardès C, Lenne PF

Sci Rep. 2015 Jul 22;5:11379 PMID: 26198871

PubMed

PUBLICATION

August 5th 2014

Clustering of low-valence particles: structure and kinetics

Markova O, Alberts J, Munro E, Lenne PF.

Phys Rev E Stat Nonlin Soft Matter Phys. 2014 Aug;90(2):022301 PMID: 25215732

PubMed

PUBLICATION

May 5th 2014

Setting up a simple light sheet microscope for in toto imaging of C. elegans development

Chardès C, Mélénec P, Bertrand V, Lenne PF.

J Vis Exp. 2014 May 5;(87) PMID: 24836407

PubMed

Pierre-françois Lenne

Coordinator, Group leader

PHONE: +33 (0)4 91 26 93 65

EMAIL: pierre-francois.lenne@univ-amu.fr

Pierre-François studied physics at the University of Paris and Ecole Normale Supérieure of Paris, France, before completing his PhD in soft matter physics at the University of Grenoble, France. After postdoctoral research in the cell biology and biophysics unit of EMBL (Heidelberg, Germany), he joined the National Centre for Scientific Research (CNRS) as a Chargé de Recherche (research scientist) in the Fresnel Institute of Marseille. Group leader at the Institute for Developmental Biology of Marseilles-Luminy (IBDM) and CNRS research director since 2009, his current research focuses on cell dynamics and mechanics in the context of tissue morphogenesis.