V. Bertrand

Polarization and binary cell fate decisions in the nervous system

 

Our team is analyzing how polarity is established in the nervous system and how this polarity controls the generation of different types of neurons

In the Labex context, our team is analyzing the mechanism of polarization of a field of neuronal precursors in the C. elegans embryo. In this project, we are using a combination of genetic approaches, in vivo quantitative imaging methods and in vitro microfluidic assays in collaboration with the teams of Pierre-François Lenne (IBDM) and Olivier Théodoly (LAI). We have also recently initiated a new project aiming at determining the mechanisms that ensure the robustness of cell fate decisions in the nervous system and the maintenance of neuronal differentiation programs during aging. In this project, we are combining CRISPR-Cas9 genome engineering approaches and in vivo quantification of transcriptional states in collaboration with the teams of Jonathan Ewbank (CIML) and Pierre-François Lenne (IBDM).

 

bandeau-vincent

 

Links

PUBLICATION

PUBLICATION

PUBLICATION

Close

Vincent Bertrand

Group leader

+33 (0)4 91 26 93 92

vincent.bertrand@univ-amu.fr

After a PhD in Marseille on early development of ascidian embryos, he did his postdoc in New York on neuronal differentiation in C. elegans. Since april 2011 he has been in charge of a research group at IBDM working on the mechanisms of polarization and specification during nervous system development using the C. elegans embryo as a model organism.

Close

Konstantina Filippopoulou

PhD student

Close

Carole Couillault

Technical staff

+33(0)4 91 26 93 94

carole.couillault@univ-amu.fr

Project title: A quantitative approach to the mechanism of polarization of a field of neuronal precursors in C. elegans

Close

Shilpa Kaur

PhD student

+33(0)4 91 26 93 94

shilpa.kaur@univ-amu.fr