Our team is analyzing how polarity is established in the nervous system and how this polarity controls the generation of different types of neurons
In the Labex context, our team is analyzing the mechanism of polarization of a field of neuronal precursors in the C. elegans embryo. In this project, we are using a combination of genetic approaches, in vivo quantitative imaging methods and in vitro microfluidic assays in collaboration with the teams of Pierre-François Lenne (IBDM) and Olivier Théodoly (LAI). We have also recently initiated a new project aiming at determining the mechanisms that ensure the robustness of cell fate decisions in the nervous system and the maintenance of neuronal differentiation programs during aging. In this project, we are combining CRISPR-Cas9 genome engineering approaches and in vivo quantification of transcriptional states in collaboration with the teams of Jonathan Ewbank (CIML) and Pierre-François Lenne (IBDM).